New paradigms will be needed to integrate resource efficient technologies and infrastructure, at-scale, into legacy systems across the electric power, mobility and agriculture sectors. These transitions, considered at the country and regional level, will require intelligent market design and sophisticated technology risk and business models. Systems that efficiently and effectively navigate these production frontiers first will generate outsized returns. At the same time, emerging economies can build infrastructure that leap-frogs existing paradigms and technologies; positioning themselves to be more efficient, flexible, resilient, and environmentally sustainable. This focus area looks to de-risk these new energy and infrastructure solutions through systems-thinking and analysis, and identify the most promising opportunities and largest risks.